Laboratory Services for Glymphatic Study
University of Exeter · South West
Key facts
- Closing date
- 08 Dec 2021
- Contract starts
- 01 Feb 2022
- Contract ends
- 30 Sep 2024
- Procedure
- Open procedure
- Buyer type
- Education
Description
The main aim of this research project is to identify, in a large cohort of PD patients, relationship between the phenotype (in motor, psychiatric, functional and cognitive symptoms, and sleep quality) of cases of sporadic or familial forms of Parkinson's disease and AQP4 SNP genetic variations as genetic modifiers of the function of the glymphatic system. This cross-sectional study aims at recruit up to 800 consecutive patients with PD across three large Centres in southern England. This tender is for the blood sample analysis collected from the participants to analyse genetic variations in up to 17 SNPs of the AQP4 gene and of genetic mutations (either pathogenic or conferring increased risk) to a panel of 13 PD-related genes (SNCA, PRKN, PARK7, PINK1, GBA, LRRK2, PLA2G6, FBXO7, VPS35, DNAJC6, SYNJ1, MAPT, LRP10).
Categories (CPV)
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