Onasemnogene Abeparvovec Intravenous (Zolgensma®) Service & Onasemnogene Abeparvovec Intrathecal (OAV101 IT) Service
NHS England · London
Key facts
- Contract value
- £26,143,000
- Awarded
- 23 Aug 2026
- Procedure
- Open procedure
- Buyer type
- Central government
- Source
- Find a Tender
Awarded to 16 suppliers
| Supplier | Value |
|---|---|
| Northern Care Alliance NHS Foundation Trust | £1,036,000 |
| University Hospitals Bristol and Weston NHS Foundation Trust | £1,036,000 |
| Sheffield Teaching Hospitals NHS Foundation Trust | £1,036,000 |
| Oxford University Hospitals NHS Foundation Trust | £1,036,000 |
| The Newcastle upon Tyne Hospitals NHS Foundation Trust | £1,036,000 |
| University Hospitals Southampton | £1,036,000 |
| University College London Hospitals NHS Foundation Trust | £1,036,000 |
| St George's University Hospitals NHS Foundation Trust | £1,036,000 |
| King's College Hospital NHS Foundation Trust | £1,036,000 |
| Great Ormond Street Hospital | £776,000 |
| Guy's and St Thomas' NHS Foundation Trust | £776,000 |
| University Hospitals of North Staffordshire NHS Trust | £776,000 |
| Sheffield Children's NHS Foundation Trust | £776,000 |
| Leeds Teaching Hospitals NHS Trust | £776,000 |
| North Manchester General Hospital | £776,000 |
| Alder Hey Children's NHS Foundation Trust | £776,000 |
Description
Intention to award the Onasemnogene Abeparvovec Intravenous (Zolgensma®) Service & Onasemnogene Abeparvovec Intrathecal (OAV101 IT) Service.
This is a a one-time, in vivo gene replacement therapy, for use in babies aged 12 months and under, that utilises an adeno-associated virus serotype 9 (AAV9) vector, modified to contain a functional copy of the human SMN1 gene. It is administered intravenously, allowing the vector to deliver the gene into motor neurones and peripheral tissues, enabling the sustained expression of survival motor neuron (SMN) protein, which is deficient or mutated in individuals with SMA.
Onasemnogene abeparvovec intrathecal (OAV101 IT) is a one-time in vivo gene replacement therapy for patients with SMA, proposed to treat individuals with SMA aged 2 years and over. This intrathecal injection will be used to treat a distinct cohort of SMA patients to Zolgensma. It will be assessed via NICE’s technology appraisal programme, with an expected final guidance publication date in late 2026.
Procurement was carried out in Lots for the services as detailed above. Contract values are estimated and will be dependent on number of patients actually treated at each awarded provider.
Categories (CPV)
- 85100000 Health services
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