GOSH - NHS GMS Alliance ctDNA national transformation project Health Economics
Great Ormond Street Hospital for Children NHS Foundation Trust · United Kingdom
Key facts
- Estimated value
- £150,000
- Closing date
- 20 Jan 2023
- Contract starts
- 01 Mar 2023
- Contract ends
- 31 Dec 2023
- Procedure
- Open procedure (below threshold)
- Buyer type
- Health
Description
The NHS Genomic Medicine Service infrastructure, including the seven Genomic Laboratory Hubs (GLHs), enable the full repertoire of genomics testing for cancer patients in the NHS in England as outlined in the National Genomic Test Directory (Test Directory). Most of the somatic cancer testing in the Test Directory is based on testing the genetic make-up of an individual's tumour. This requires a tumour sample to be taken and then sent to the GLHs for testing. Increasingly it is becoming possible to use blood samples to test the circulating free DNA (cfDNA) for the presence of disease-causing mutations in circulating tumour DNA (ctDNA), also known as liquid biopsy testing. ctDNA based testing has now been validated, pan-cancer, in a number of different trials including I-SPY2, FLAUAS, AURA3, SCRUM-Japan, GOZILA, GRECO, MYSTIC, PEGASUS, COBRA, SOLAR1 and plasmaMATCH. ctDNA testing for EGFR gene mutations is already included on the Test Directory for lung cancer patients. To build the evidence base for the further roll out of ctDNA testing in the NHS, NHS England convened a group of experts to scope a project to explore ctDNA starting with suspected stage 3/4 non-small cell lung cancer patients. ctDNA samples will be taken from at least 700 patients with suspected thoracic malignancy without a confirmed histological diagnosis of stage 3/4 non-small cell lung cancer for direct gene panel analysis for those genes already approved on the Test Directory. ctDNA samples taken prior to the start of this project for patients with non-small cell lung cancer taken at the same time as tissue biopsy or after histological verification in parallel to tissue molecular analyses will also be included in this health economics evaluation. Numbers to be confirmed.
We publish all our opportunities on the Health Family eCommercial System
https://health-family.force.com/s/Welcome
Categories (CPV)
- 73111000 Research laboratory services
Similar open tenders
Pay and Reward Strategy
Location: LondonBuyer: Office of Rail and Road
Open tenderCloses 3 Dec, 202628 daysValue £55.00kSource Find a TenderThe Office of Rail and Road has committed to carry out a comprehensive review of its Pay and Reward Strategy for all pay grades below the Senior Civil Service (SCS). The aim is to ensure that ORR has a strategy in place that delivers an equitable and consistent approach to pay and reward which is understood and suppor
Research Services for Pensions illustrations: presenting uncertainty and variability
Location: LondonBuyer: THE FINANCIAL REPORTING COUNCIL LIMITED
Open tenderCloses 7 Dec, 202632 daysValue £125.00kSource Find a TenderThe Financial Reporting Council (FRC) regulates auditors, accountants and actuaries and sets the UK's Corporate Governance and Stewardship Codes. As the Competent Authority for audit in the UK, we set auditing and ethical standards and monitor and enforce audit quality. The FRC requires Research Services to examine how
AI Creator Control
Location: WalesBuyer: Intellectual Property Office
Open tenderCloses 28 Nov, 202623 daysValue £80.00kSource Find a TenderThe IPO requires a supplier to provide research to support this review. The intention is that this will be a four-month project including an interim report (shared with policy officials) and final report (prepared for external publication). The Government may wish to communicate initial findings from the interim report
Mapping the Research and Innovation Ecosystem in select North African countries Priorities Actors and Uk Partnership Opportunities in Algeria Egypt Morocco and Tunisia
Location: LondonBuyer: British Council
Open tenderCloses 25 Nov, 202620 daysValue £70.00kSource Find a TenderThe British Council invites proposals to conduct a market intelligence study titled Mapping the Research and Innovation Ecosystem in Selected North African Countries Priorities Actors and Uk Partnership Opportunities covering Algeria Egypt Morocco and Tunisia
Westgate Vision 2040 - Multi-Disciplinary Design Team (MDDT) Consultancy Service
Location: IrelandBuyer: Louth County Council
Open tenderCloses 25 Nov, 202620 daysValue €900.00KSource TEDDelivery of detailed design, tender and management of construction phase to handover for Westgate Vision Public Realm Scheme Character Area 1 and 2
Ireland West SDZ Designated Activity Company DAC is seeking consultancy services to support the development of an Aviation Circular Economy Hub at Ireland West Airport Knock.
Location: IrelandBuyer: Mayo County Council
Open tenderCloses 24 Nov, 202619 daysValue €125.00KSource TEDMCC are publishing this competition on behalf of Ireland West SDZ Designated Activity Company. The brief is to undertake the market validation, technical, commercial and operational planning development work necessary to establish the proposed Hub’s viability. The tenderer shall identify an appropriate operating model